Charlestown is the oldest neighborhood in Boston, Massachusetts, in the United States. Also called Mishawum by the Massachusett, it is located on a peninsula north of the Charles River, across from downtown Boston, and also adjoins the Mystic River and Boston Harbor waterways. Charlestown was laid out in 1629 by engineer Thomas Graves, one of its earliest s…Charlestown is the oldest neighborhood in Boston, Massachusetts, in the United States. Also called Mishawum by the Massachusett, it is located on a peninsula north of the Charles River, across from downtown Boston, and also adjoins the Mystic River and Boston Harbor waterways. Charlestown was laid out in 1629 by engineer Thomas Graves, one of its earliest settlers, during the reign of Charles I of England. It was originally a separate town and the first capital of the Massachusetts Bay Colony.