Apopka is a city in Orange County, Florida. The city's population was 54,873 at the 2020 census. It is part of the Orlando–Kissimmee–Sanf…Apopka is a city in Orange County, Florida. The city's population was 54,873 at the 2020 census. It is part of the Orlando–Kissimmee–Sanford Metropolitan Statistical Area. Apopka comes from Seminole word Ahapopka for "potato-eating place".