cathepsin C (DPPI); trimming of the amino termini of cysteine cathepsins 121). Functions 1–3 (function 3 being a combination of functions 1 and 2) are of crucial importance in disease. Protease ...

They believe it may inhibit the cysteine proteases (protein degrading enzymes) that are overexpressed in cancer cells. “We then derivatized arteannuin B by chemically reducing it, and Dr. Lin showed ...

How do enzymes cause tremendous increases in reaction rates? Learn how a group of enzymes called the serine proteases work.

Their new discovery is detailed in the paper titled "Design of novel and highly selective SARS-CoV-2 main protease inhibitors ...

While spice allergies are rare, a certain enzyme found in ginger (cysteine proteinase GP-1) may trigger allergic reactions in ...

Viral proteases utilize many different catalytic mechanisms and ... Michaelis complexes (substrate bound complexes), acyl-enzyme complexes (for the serine and cysteine proteases), and product ...

In particular, we focus on understanding the role of cysteine-mediated protein activities in cancer and degenerative diseases associated with aging. These activities comprise proteases, ...

This study presents a valuable finding on the molecular mechanisms that govern GABAergic inhibitory synapse function. The authors propose that Endophilin A1 serves as a novel regulator of GABAergic ...

The School of Neurobiology, Biochemistry & Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel ...

In particular, we have characterized glutaredoxin (thioltransferase) as the TDOR enzyme that displays specificity and high catalytic efficiency for protein-SSG substrates, including hemoglobin-SSG, ...