The substrate goes through a chemical reaction and changes into a new molecule called the product — sort of like when a key goes into a lock and the lock opens. Since most reactions in your body’s ...

Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...

Researchers have made a significant breakthrough in understanding how certain pathogens defend themselves against the host's ...

The active site of an enzyme has a unique three-dimensional structure that allows it to bind to a specific substrate, much like a lock and key. This specificity ensures that enzymes catalyze only the ...

The cell can control a metabolic pathway by the presence or absence of a particular enzyme. The cell can also regulate the rate of reaction of key enzymes. Enzymes are able to bind to their ...

Researchers at the Center for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy ...

SEPTEMBER 3, 2020 — UTSA researchers have discovered how 3-hydroxyanthranilate-3,4-dioxygenase, an enzyme known as HAO that is involved ... “From a medical perspective, the HAO enzymatic mechanism is ...

With the continuous rise in antibiotic resistance, novel methods that can reveal currently unknown antibiotic resistance mechanisms are essential to prepare and inform health responses. Here we built ...

Metabolic enzymes, typically associated with energy production, are now discovered to also play essential roles in the nucleus, such as orchestrating cell division and DNA repair. This breakthrough, ...

The researchers found that ATP-citrate lyase (ACLY), an enzyme involved in converting citrate to acetyl-CoA, plays a critical role in activating SASP. This discovery was made using advanced ...

Altered target enzymes (increased dihydrofolate reductase activity or expression, kinetically altered dihydrofolate reductase, increased 5-aminoimidazole-4-carboxamide ribonucleotide ...

The study uncovered the evolutionary and molecular mechanisms by which zinc-dependent macrodomains reverse ADP-ribosylation, a key modification in cellular processes Structural analysis showed that ...