In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins. A ...

demonstrating the proficiency of MZ1 to position the target protein for degradation and the favorability of the target protein for ubiquitination by UBE2R1. The importance of degraders for ...

The study is published in the Proceedings of the National Academy of Sciences in an article titled, “Targeted degradation of ...

"This makes it highly suitable for many of the experiments and processes today widely used in the field of targeted protein degradation. Dr. Zollman, co-corresponding author on the study ...

In addition to biochemical experiments and mass spectrometry ... More information: Wai Tuck Soh et al, Protein degradation by human 20S proteasomes elucidates the interplay between peptide ...

The Centre for Protein Degradation was developed out of years of degraders research by scientists who explored targeted protein degradation (TPD) as a therapeutic modality. Our extensive structural ...

Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized and conserved population of highly absorptive lysosome rich enterocytes (LREs). The gut microbiome has ...

RIVERSIDE, Calif. -- In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing ...

The Centre for Protein Degradation is a centre of excellence coordinating all aspects of molecularly driven protein degradation, from concept to clinic, both within and beyond the ICR. Targeted ...