In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins. A ...

demonstrating the proficiency of MZ1 to position the target protein for degradation and the favorability of the target protein for ubiquitination by UBE2R1. The importance of degraders for ...

Many experiments had shown that DNA is the ... the cellular machinery involved in the degradation of aging proteins. Inhibition of autophagy (a process by which cells engulf themselves) also ...

In addition to biochemical experiments and mass spectrometry ... More information: Wai Tuck Soh et al, Protein degradation by human 20S proteasomes elucidates the interplay between peptide ...

"This makes it highly suitable for many of the experiments and processes today widely used in the field of targeted protein ...

The Centre for Protein Degradation was developed out of years of degraders research by scientists who explored targeted protein degradation (TPD) as a therapeutic modality. Our extensive structural ...

Novel method identified protein degraders that target Pin1, a protein involved in pancreatic cancer development.

In lab experiments, researchers from the company’s cutting-edge laboratory in Tsukuba found that ASP3082 powerfully induced protein degradation and subsequently inhibited downstream signaling ...

C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of ...

Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized and conserved population of highly absorptive lysosome rich enterocytes (LREs). The gut microbiome has ...

The Centre for Protein Degradation is a centre of excellence coordinating all aspects of molecularly driven protein degradation, from concept to clinic, both within and beyond the ICR. Targeted ...