The adaptors activate other relay proteins inside the cell, and this chain of protein-protein interactions creates a signal transduction pathway that links an activated receptor to its response.

You will be redirected to our submission process. This Research Topic is the second volume of “The Role of Toll-like Receptors and their Related Signaling Pathways in Viral Infection and Inflammation” ...

Immune cells are capable of detecting infections just like a sniffer dog, using special sensors known as Toll-like receptors ...

All members of this superfamily signal inflammation in a similar manner. This is due to the presence of a conserved protein sequence in the cytosolic domain called the Toll–IL-1 receptor (TIR) domain, ...