They found that molecular components that induced protein degradation could be used to convert multiple different inhibitors ...
CaMKII activates the HRI/eIF2α signaling pathway and inhibits the proteotoxicity induced by proteasome inhibition through ...
Antimicrobial design; targeted protein degradation; mTORC1 inhibition; enzyme structure-function studies. My laboratory uses approaches derived from both chemistry and biology. Projects include ...
Mice express full-length protein ZBP1-L as well as an alternatively-spliced shorter isoform (ZBP1-S) containing only its two ...
Maize (corn) is one of the most important staple crops in the world and has been extensively studied. Yet, many aspects of ...
These cells deploy complex cytoskeletal rearrangements to recognize and eliminate potential threats 3. Even in the steady state, myeloid cells constantly survey their surroundings for potential ...
In summary, these BLI data demonstrate that B. subtilis MinD is capable of binding membrane in both monomeric and dimeric form, while the presence of ATP in the binding pocket appears to affect both ...
Conversion of functionally undefined homopentameric protein PbaA into a proteasome activator by mutational modification of its C-terminal segment conformation. Protein Eng. Des. Sel. 31, 29-36 (2018).
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