In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins. A ...

Proteases catalyse the hydrolyis of peptide bonds in proteins, often in a very precise way, and are thereby involved in the control of a number of important physiological processes including cell ...

Researchers from the Universitat Jaume I of Castelló (Spain) and the Max Planck Institute (Germany) have developed new ...

Stress granules (SGs) form in response to diverse environmental signals. Here, the signaling pathways that connect lysosomal ...

activity-based Ub probes and inhibitors against deubiquitinases (DUBs). We also develop new PROTAC (proteolysis-targeting chimera) strategies for targeted protein degradation for treating human ...

The four main classes, which most people are treated with, target one of three viral proteins which control HIV’s lifecycle: reverse transcriptase, integrase and protease ... Integrase inhibitors ...

C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of ...

Watch Professors Udai Banerji and Ian Collins talk about their work on AKT inhibitors. AKT – which is also known as Protein Kinase B, or PKB – is an enzyme that plays a key role in a mechanism that ...

Carbonic anhydrase inhibitors show potential in reducing tau protein buildup, offering new therapeutic avenues for neurodegenerative diseases like tauopathies.

In drug discovery, targeted protein ... Pin1 inhibitors that can penetrate cancer-associated fibroblasts and/or cancer cells ...