gut.bmj6d
Induction of macrophage efferocytosis in pancreatic cancer via PI3Kγ inhibition and radiotherapy promotes tumour control
Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...
gut.bmj12d
Construction of exosome non-coding RNA feature for non-invasive, early detection of gastric cancer patients by machine learning: a multi-cohort study
Background and objective Gastric cancer (GC) remains a prevalent and preventable disease, yet accurate early diagnostic ...
gut.bmj13d
Aspirin is associated with lower risk of pancreatic cancer and cancer-related mortality in patients with diabetes mellitus
Background Patients with type 2 diabetes mellitus (T2DM) have higher pancreatic cancer (PC) risk. While aspirin has chemopreventive effects on digestive cancers, its effect on PC among patients with ...
gut.bmj13d
Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade
Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered ...
gut.bmj13d
Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study
Objective Faecal microbiota transplantation (FMT) from healthy donors to patients with irritable bowel syndrome (IBS) has been attempted in two previous double-blind, placebo-controlled studies. While ...
gut.bmj10d
Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
Objective Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced from studies in animals. The aim of the study is to characterise ...
gut.bmj9d
Functional GI disorders: from animal models to drug development
UCLA Center for Neurovisceral Sciences & Women’s Health, Departments of Medicine, Physiology and Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA UCLA Center for Neurovisceral ...
gut.bmj14d
Role of the microbiome in human development
Correspondence to Professor Maria Gloria Dominguez-Bello, Department of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, NJ 08901, USA; ...
gut.bmj9d
Intestinal ganglioneuromatosis and multiple endocrine neoplasia type 2B: implications for treatment
Dr V V Smith, Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK. Three infants, who presented with intestinal obstruction due to ...
gut.bmj6d
Intestinal reticulosis as a complication of idiopathic steatorrhoea
Three patients who had idiopathic steatorrhoea associated with reticulosarcoma of either the jejunum or the ileum are described. Previously reported cases with these features are reviewed and the ...
gut.bmj8d
Endoscopic full-thickness plication for the treatment of PPI-dependent GERD: results from a randomised, sham controlled trial
Background The majority of endoscopic antireflux procedures for GERD are cumbersome to use and randomised long-term data are sparse. We conducted such a trial to determine the efficacy and safety of a ...
gut.bmj3d
Pathophysiology of functional dyspepsia
Functional dyspepsia is a symptom complex characterised by postprandial upper abdominal discomfort or pain, early satiety, nausea, vomiting, abdominal distension, bloating, and anorexia in the absence ...