Hepatitis C is one of the most common viral infections ... Another group of medicines, proton pump inhibitors (PPI), can also lower Epclusa's effectiveness. Examples are esomeprazole (Nexium ...

The inhibitors bind to the catalytic zinc ion within the enzyme cavity. Several such derivatives are clinically used inhibitors, such as acetazolamide, methazolamide, ethoxzolamide ...

"When it comes to animal models, mice and rats are most commonly used to test experimental amyloid inhibitors. They both have their advantages, but neither compares to the free-living nematode C.

Proton pump inhibitors (PPIs) are a group of drugs whose purpose it is to reduce stomach acid. They have been used to treat a wide of gastric acid-related illnesses for more than 30 years and are ...

State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China ...

hepatitis C virus; mRNA, messenger RNA; PI, protease inhibitor; NS, nonstructural protein; RdRp, RNA-dependent RNA polymerase; —, no drugs in this class in this phase of development.

ACE inhibitors are best known for treating high blood pressure. They work by targeting the hormone angiotensin II. Angiotensin-converting enzymes (ACE) inhibitors help blood vessels to relax and open.

There are different types of hepatitis viruses, including hepatitis B (HBV) and hepatitis C (HCV), which are distinct viruses that share some similarities. Though both viral strains can be transmitted ...

In the era of DAAs, adherence is paramount to treatment success given the strict dosing regimen of first generation HCV protease inhibitors (PIs). First generation DAAs have high pill burdens and ...

therapy for hepatitis C (HCV) offers high cure rates to those able to adhere to standard durations of treatment. In low- and middle-income countries, where treatment is limited to second-generation ...

The patients were treated with Peg-IFN and ribavirin (RBV) for 48 or 24 weeks (for patients with HCV genotype 1 and other genotypes ... Cells were lysed in RIPA buffer (Sigma) supplemented with ...