In addition, the westbound US 60 (Superstition Freeway) ramp to eastbound I-10 will be closed from 10 p.m. Friday to 5 a.m.
There will be notable restrictions and closures on Loop 101 and Interstate 10, as well as on- and off-ramp closures.
The Arizona Department of Transportation advises drivers to allow extra travel time or take alternative routes on closed or restricted freeways.
Work crews will be on the roads beginning Friday through Monday morning on multiple freeways for construction this weekend.