Introduction: Plasminogen activator inhibitor-1 (PAI-1) is linked to thrombosis and ... During fibrinolysis, plasmin degrades fibrin into fibrin degradation products (FDP), including the clinically ...
The proteasomal and autophagic degradation of proteins are two major pathways for protein quality control in the cell ... The RIPA buffer was supplemented with EDTA-free protease inhibitor cocktail ...
CaMKII activates the HRI/eIF2α signaling pathway and inhibits the proteotoxicity induced by proteasome inhibition through ...
Mice express full-length protein ZBP1-L as well as an alternatively-spliced shorter isoform (ZBP1-S) containing only its two ...
These cells deploy complex cytoskeletal rearrangements to recognize and eliminate potential threats 3. Even in the steady state, myeloid cells constantly survey their surroundings for potential ...
The four main classes, which most people are treated with, target one of three viral proteins which control HIV’s lifecycle: reverse transcriptase, integrase and protease ... Integrase inhibitors ...
activity-based Ub probes and inhibitors against deubiquitinases (DUBs). We also develop new PROTAC (proteolysis-targeting chimera) strategies for targeted protein degradation for treating human ...
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