The researchers discovered that modulation of a specific molecular cascade, the mTOR signaling pathway, in these stem cell models induces a dormant state remarkably akin to diapause. "The mTOR pathway ...

Mitigating inflammation, inhibiting immunosenescence, and eliminating senescent cells could be promising strategies for enhancing vaccine responses in older people. The mTOR signalling pathway greatly ...

Chromatin immunoprecipitation (ChIP-seq) is the most common approach to observe global binding of proteins to DNA in vivo. The occupancy of transcription factors (TFs) from ChIP-seq agrees well with ...

Two new papers by a team of researchers at Boston University, the Indiana University School of Medicine and the Alzheimer’s Disease Neuroimaging Initiative (ADNI), and the German Center for ...

FAO is catalyzed by the mitochondrial trifunctional protein (MTP) and, if overloaded, generates ROS. ROS are boosted during ...

The inhibition of ERK5 is a potential complementary strategy for countering FAK inhibitor resistance in patients with lung ...

Several factors influence whether certain cells and tissues can survive and function after an organism dies. These include environmental conditions, metabolic activity and preservation techniques.

CUTS is a cryptic exon RNA biosensor enabling real-time detection of TDP-43 loss of splicing function. CUTS exhibits a significant linear relationship with TDP-43 loss. CUTS can deliver an ...

In glaucoma, the disturbed pathways involve lipid metabolism and the carnitine shuttle pathway, with increased and decreased ...

Scientists have revealed how a population of insulin-producing cells (IPCs) in the fruit fly brain works together to produce a concerted response to metabolic demands and internal state changes.

This review uniquely explores the intricate crosstalk between apoptosis, necroptosis, and other cell death pathways, discussing their roles and interactions in the pathogenesis of cardiac involvement ...