KEY TAKEAWAYS Flights continued to be cancelled in the U.S. on Wednesday, as the historic winter storm that hit Louisiana, Texas and other Gulf Coast states continued spreading for a second day.As many as 69% of departures out of New Orleans Wednesday have been cancelled,

With winter weather striking the Southeastern United States on Tuesday and blanketing several states with snow and ice, travel via plane, train or car has become challenging.

Refugees who were slated to travel to the United States after a years-long and often cumbersome process have had their flights canceled, according to a State Department memo to resettlement partners obtained by CNN.

Storm Enzo has severely impacted airports across several states, leading to the closure of airports in Houston and Jacksonville.

Thousands of flights at three airports were canceled amid a storm that caused "extremely hazardous" travel conditions in the Houston region.