The inhibitors bind to the catalytic zinc ion within the enzyme cavity. Several such derivatives are clinically used inhibitors, such as acetazolamide, methazolamide, ethoxzolamide ...

"When it comes to animal models, mice and rats are most commonly used to test experimental amyloid inhibitors. They both have their advantages, but neither compares to the free-living nematode C.

State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China ...

hepatitis C virus; mRNA, messenger RNA; PI, protease inhibitor; NS, nonstructural protein; RdRp, RNA-dependent RNA polymerase; —, no drugs in this class in this phase of development.

ACE inhibitors are best known for treating high blood pressure. They work by targeting the hormone angiotensin II. Angiotensin-converting enzymes (ACE) inhibitors help blood vessels to relax and open.

while the potential high-risk toxicity of HCV protease inhibitors needs to be further evaluated in HIV–HCV-coinfected patients. In general, HAART should first be initiated in patients with HCV ...