Assessing the efficacy of clinical drugs targeting SARS-CoV-2 main protease
Over the last few years, the SARS-CoV-2 virus, responsible for COVID-19, has undergone significant changes, evolving from the ...
Cocrystal Pharma Reports Third Quarter 2024 Financial Results and Provides Updates on its Antiviral Drug-Development Programs
BOTHELL, Wash., Nov. 13, 2024 (GLOBE NEWSWIRE) -- Cocrystal Pharma, Inc. (Nasdaq: COCP) (“Cocrystal” or the “Company”) reports financial results for the three and nine months ended September 30, 2024, ...
eLife2d
Endophilin A1 facilitates organization of the GABAergic postsynaptic machinery to maintain excitation-inhibition balance
This study presents a valuable finding on the molecular mechanisms that govern GABAergic inhibitory synapse function. The authors propose that Endophilin A1 serves as a novel regulator of GABAergic ...
Cocrystal Pharma Advances Antiviral Drug Development
Cocrystal Pharma ( (COCP) ) has issued an announcement. Cocrystal Pharma, Inc. is leveraging its innovative, structure-based drug discovery ...
C&EN9d
Structure-Based Design of Covalent SARS-CoV-2 Papain-like Protease Inhibitors
Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States Center for Advanced Biotechnology and ...
Medscape2d
Clinical Significance of HIV Reverse-transcriptase Inhibitor-resistance Mutations
CRF: Circulating recombinant form; NNRTI: Non-nucleoside reverse-transcriptase inhibitor; NRTI: Nucleos(t)ide analog reverse-transcriptase inhibitor. Eight nucleos(t)ide analog reverse ...
Medscape28d
JAK Inhibitors, Biologics Show Nuanced Differences in Rheumatoid Arthritis Pain Outcomes
Janus kinase (JAK) inhibitors had a marginally superior effect on pain relief when compared with tumor necrosis factor (TNF) inhibitors in patients with rheumatoid arthritis (RA), particularly ...
C&EN11d
Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2R3, Canada Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada Department ...