This study presents a valuable finding on the molecular mechanisms that govern GABAergic inhibitory synapse function. The authors propose that Endophilin A1 serves as a novel regulator of GABAergic ...

In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins.

Over the last few years, the SARS-CoV-2 virus, responsible for COVID-19, has undergone significant changes, evolving from the original wild-type strains to the highly transmissible Omicron variant.

Cocrystal Pharma ( (COCP) ) has issued an announcement. Cocrystal Pharma, Inc. is leveraging its innovative, structure-based drug discovery ...

Savella (milnacipran) is another common SNRI and is used to manage fibromyalgia. Selective serotonin reuptake inhibitors (SSRIs) and SNRIs are both antidepressants but work differently. SSRIs work by ...

Proton pump inhibitors (PPIs) are a group of drugs whose purpose it is to reduce stomach acid. They have been used to treat a wide of gastric acid-related illnesses for more than 30 years and are ...

ACE inhibitors are best known for treating high blood pressure. They work by targeting the hormone angiotensin II. Angiotensin-converting enzymes (ACE) inhibitors help blood vessels to relax and open.

For immunoprecipitation (IP), whole-cell extracts were collected 24-48 hours after transfection and lysed in RIPA buffer (1% [vol:vol] Triton X-100, 100 mM Tris-HCl, 50 mM EDTA, 150 mM NaCl, 1% ...

Capital structure describes the mix of a firm's long-term capital—a mix of debt and equity—that it uses to fund its ongoing operations and future growth. A company's capital structure is ...