In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins. A ...

demonstrating the proficiency of MZ1 to position the target protein for degradation and the favorability of the target protein for ubiquitination by UBE2R1. The importance of degraders for ...

Many experiments had shown that DNA is the ... the cellular machinery involved in the degradation of aging proteins. Inhibition of autophagy (a process by which cells engulf themselves) also ...

An international leader in the study of protein degradation – considered one of the most promising areas of drug discovery – has joined The Institute of Cancer Research, London. Dr Zoran Rankovic has ...

In addition to biochemical experiments and mass spectrometry ... More information: Wai Tuck Soh et al, Protein degradation by human 20S proteasomes elucidates the interplay between peptide ...

"This makes it highly suitable for many of the experiments and processes today widely used in the field of targeted protein ...

Novel method identified protein degraders that target Pin1, a protein involved in pancreatic cancer development.

The Centre for Protein Degradation was developed out of years of degraders research by scientists who explored targeted protein degradation (TPD) as a therapeutic modality. Our extensive structural ...

Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized and conserved population of highly absorptive lysosome rich enterocytes (LREs). The gut microbiome has ...

A team of scientists has used a novel approach to identify protein degraders that target Pin1, a protein involved in pancreatic cancer development.