In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins. A ...

Proteases catalyse the hydrolyis of peptide bonds in proteins, often in a very precise way, and are thereby involved in the control of a number of important physiological processes including cell ...

Novel method identified protein degraders that target Pin1, a protein involved in pancreatic cancer development.

Over the last few years, the SARS-CoV-2 virus, responsible for COVID-19, has undergone significant changes, evolving from the ...

The Centre for Targeted Protein Degradation (CeTPD) at the University of Dundee is one of the world's leading centers for ...

The four main classes, which most people are treated with, target one of three viral proteins which control HIV’s lifecycle: reverse transcriptase, integrase and protease ... Integrase inhibitors ...

activity-based Ub probes and inhibitors against deubiquitinases (DUBs). We also develop new PROTAC (proteolysis-targeting chimera) strategies for targeted protein degradation for treating human ...

C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of ...

Watch Professors Udai Banerji and Ian Collins talk about their work on AKT inhibitors. AKT – which is also known as Protein Kinase B, or PKB – is an enzyme that plays a key role in a mechanism that ...

Conversion of functionally undefined homopentameric protein PbaA into a proteasome activator by mutational modification of its C-terminal segment conformation. Protein Eng. Des. Sel. 31, 29-36 (2018).

The liberated peptides exhibit up to 17 distinct bioactivities, as shown by the in silico digestion of the protein using ... CaMPDE inhibitor, activators of ubiquitin-mediated proteolysis, alpha ...