KIC cachectic PDAC mice exhibit severe sarcopenia with loss of muscle mass and strength associated with reduced muscle fiber’s size and induction of protein degradation processes ...
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Protein degradation strategy offers hope in cancer therapyIn drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins. A ...
Novel method identified protein degraders that target Pin1, a protein involved in pancreatic cancer development.
Over the last few years, the SARS-CoV-2 virus, responsible for COVID-19, has undergone significant changes, evolving from the ...
The liberated peptides exhibit up to 17 distinct bioactivities, as shown by the in silico digestion of the protein using ... CaMPDE inhibitor, activators of ubiquitin-mediated proteolysis, alpha ...
In the early phase of Alzheimer’s disease, astrocytes are the primary source of APOE in the brain. This study examined the ...
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