In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins. A ...

Proteases catalyse the hydrolyis of peptide bonds in proteins, often in a very precise way, and are thereby involved in the control of a number of important physiological processes including cell ...

Targeted protein degradation (TPD) is getting a lot of attention as a promising modality to treat a variety of diseases from cancer to Alzheimer’s. By taking proteins down the cell’s own degradation ...

Novel method identified protein degraders that target Pin1, a protein involved in pancreatic cancer development.

Researchers from the Universitat Jaume I of Castelló (Spain) and the Max Planck Institute (Germany) have developed new ...

The approach could also allow researchers to discover drugs that target proteins which have previously proved ‘undruggable’ with inhibitor-type cancer drugs. The Centre for Protein Degradation was ...

The Centre for Targeted Protein Degradation (CeTPD) at the University of Dundee is one of the world's leading centers for ...

activity-based Ub probes and inhibitors against deubiquitinases (DUBs). We also develop new PROTAC (proteolysis-targeting chimera) strategies for targeted protein degradation for treating human ...

Carbonic anhydrase inhibitors show potential in reducing tau protein buildup, offering new therapeutic avenues for neurodegenerative diseases like tauopathies.

Watch Professors Udai Banerji and Ian Collins talk about their work on AKT inhibitors. AKT – which is also known as Protein Kinase B, or PKB – is an enzyme that plays a key role in a mechanism that ...

Conversion of functionally undefined homopentameric protein PbaA into a proteasome activator by mutational modification of its C-terminal segment conformation. Protein Eng. Des. Sel. 31, 29-36 (2018).